Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus
Identifieur interne : 000832 ( Main/Exploration ); précédent : 000831; suivant : 000833Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus
Auteurs : Kyung-Soo Inn [Corée du Sud] ; Yuri Kim [Corée du Sud] ; Abdimadiyeva Aigerim [Corée du Sud] ; Uni Park [Corée du Sud] ; Eung-Soo Hwang [Corée du Sud] ; Myung-Sik Choi [Corée du Sud] ; Yeon-Sook Kim [Corée du Sud] ; Nam-Hyuk Cho [Corée du Sud]Source :
- Virology [ 0042-6822 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Dipeptidyl peptidase 4.
- anatomopathologie : Infections à coronavirus.
- sang : Dipeptidyl peptidase 4, Interleukine-10, Protéines de la famille de l'EGF.
- Concentration inhibitrice 50, Expectoration, Humains, Plasma sanguin.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Dipeptidyl Peptidase 4.
- chemical , blood : Dipeptidyl Peptidase 4, EGF Family of Proteins, Interleukin-10.
- chemistry : Plasma, Sputum.
- pathology : Coronavirus Infections.
- Humans, Inhibitory Concentration 50.
Abstract
Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity. The concentration of sDPP4 in the plasma of MERS patients (474.76 ± 108.06 ng/ml) was significantly lower than those of healthy controls (703.42 ± 169.96 ng/ml), but there were no significant differences among the patient groups. Interestingly, plasma levels of IL-10 and EGF were negatively and positively correlated with sDPP4 concentrations, respectively. The sDPP4 levels in sputa were less than 300 ng/ml. Viral infection was inhibited by 50% in the presence of more than 8000 ng/ml of sDPP4. Therefore, sDPP4 levels in the plasma of MERS patients are significantly reduced below the threshold needed to exert an antiviral effect against MERS-CoV infection.
Url:
DOI: 10.1016/j.virol.2018.03.015
PubMed: 29587190
PubMed Central: 7112025
Affiliations:
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coronavirus</title><author><name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name><affiliation wicri:level="4"><nlm:aff id="aff0010">Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0015">Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name><affiliation wicri:level="4"><nlm:aff id="aff0010">Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0015">Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><affiliation wicri:level="4"><nlm:aff id="aff0010">Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0015">Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Hwang, Eung Soo" sort="Hwang, Eung Soo" uniqKey="Hwang E" first="Eung-Soo" last="Hwang">Eung-Soo Hwang</name><affiliation wicri:level="4"><nlm:aff id="aff0010">Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name><affiliation wicri:level="4"><nlm:aff id="aff0010">Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Division of Infectious Diseases, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Diseases, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015</wicri:regionArea><wicri:noRegion>Daejeon 35015</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name><affiliation wicri:level="4"><nlm:aff id="aff0010">Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0015">Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0025">Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (pathology)</term><term>Dipeptidyl Peptidase 4 (analysis)</term><term>Dipeptidyl Peptidase 4 (blood)</term><term>EGF Family of Proteins (blood)</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Interleukin-10 (blood)</term><term>Plasma (chemistry)</term><term>Sputum (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Concentration inhibitrice 50</term><term>Dipeptidyl peptidase 4 (analyse)</term><term>Dipeptidyl peptidase 4 (sang)</term><term>Expectoration ()</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Interleukine-10 (sang)</term><term>Plasma sanguin ()</term><term>Protéines de la famille de l'EGF (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>EGF Family of Proteins</term><term>Interleukin-10</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plasma</term><term>Sputum</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Dipeptidyl peptidase 4</term><term>Interleukine-10</term><term>Protéines de la famille de l'EGF</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Inhibitory Concentration 50</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Concentration inhibitrice 50</term><term>Expectoration</term><term>Humains</term><term>Plasma sanguin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity. The concentration of sDPP4 in the plasma of MERS patients (474.76 ± 108.06 ng/ml) was significantly lower than those of healthy controls (703.42 ± 169.96 ng/ml), but there were no significant differences among the patient groups. Interestingly, plasma levels of IL-10 and EGF were negatively and positively correlated with sDPP4 concentrations, respectively. The sDPP4 levels in sputa were less than 300 ng/ml. Viral infection was inhibited by 50% in the presence of more than 8000 ng/ml of sDPP4. Therefore, sDPP4 levels in the plasma of MERS patients are significantly reduced below the threshold needed to exert an antiviral effect against MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Andrieu, T" uniqKey="Andrieu T">T. Andrieu</name></author><author><name sortKey="Thibault, V" uniqKey="Thibault V">V. Thibault</name></author><author><name sortKey="Malet, I" uniqKey="Malet I">I. Malet</name></author><author><name sortKey="Laporte, J" uniqKey="Laporte J">J. Laporte</name></author><author><name sortKey="Bauvois, B" uniqKey="Bauvois B">B. Bauvois</name></author><author><name sortKey="Agut, H" uniqKey="Agut H">H. Agut</name></author><author><name sortKey="Cahour, A" uniqKey="Cahour A">A. 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Kim</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name></region><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name><name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name><name sortKey="Hwang, Eung Soo" sort="Hwang, Eung Soo" uniqKey="Hwang E" first="Eung-Soo" last="Hwang">Eung-Soo Hwang</name><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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